This doesn't apply for Mom as you can't exit her room after beating her (unless carrying Teleport!, Cursed Skull, 0 The Fool Tarot Card, Hermit Tarot Card, The Stars Tarot Card, The Moon Tarot Card, IV The Emperor, or a Telepill). The earlier you find the Boss Room, Treasure Room or the Shop, the better as it allows more chances to reroll the items. It is advisable on the earlier floors, where there is less danger, to explore all the rooms on the floor to charge The Dice in case a reroll is needed.In many cases it's better to just get the item, because it's often not worth it to swap a bad item for something that could be even worse. 'Rerolling' doesn't mean that you'll always get a better item.The Ankh will allow Isaac to turn into ? if he dies, even if you haven't unlocked him. Simply die before you fight Mom's Heart/ It Lives!, kill them as ?, and The Dice will be unlocked. If you are shooting for the D6, but do not want to have to beat all of the floors as ?, try to find the Ankh item.However, note that the Angel Room essentially has only two or three 'bad' items ( The Bible and the Prayer Card, if you want to hold on to the Dice), so bringing a fully charged dice into the Angel Room almost guarantees a good item (since if you get one of those items you can just reroll it).

For advanced players, it's not as risky to make a deal in the Devil Room early on as with most of the other playable characters due to relatively high starting health.This allows him to make powerful builds more easily.

Isaac gains a very distinctive advantage when he obtains The Dice, being able to reroll Items every six rolls.

Isaac's strength lies in his relatively high starting health but his other stats are average.

Hush isaac